InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANAPC7

Summary

InnateDB Protein

IDBP-383181.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANAPC7

Protein Name

anaphase promoting complex subunit 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000394394

InnateDB Gene

IDBG-57027 (ANAPC7)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269PubMed:18485873}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	90 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJX3