InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAM3C

Summary

InnateDB Protein

IDBP-38335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM3C

Protein Name

family with sequence similarity 3, member C

Synonyms

ILEI;

Species

Homo sapiens

Ensembl Protein

ENSP00000353025

InnateDB Gene

IDBG-38333 (FAM3C)

Protein Structure

UniProt Annotation

Function

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Subcellular Localization

Secreted {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269PubMed:16959614}. Note=Cytoplasmic in some cancer cells.

Disease Associations

Tissue Specificity

Present in most secretory epithelia (at protein level). {ECO:0000269PubMed:16959614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0007275	multicellular organismal development
GO:0008150	biological_process

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92520

PhosphoSite

PhosphoSite-Q92520

TrEMBL

C9JP35

UniProt Splice Variant

Entrez Gene

10447

UniGene

Hs.573624

RefSeq

NP_055703

HUGO

HGNC:18664

OMIM

608618

CCDS

CCDS5782

HPRD

12270

IMGT

EMBL

AC006364 AC079401 AK290682 AK292731 BC024200 BC046932 BC068526 CH471070 D87120

GenPept

AAH24200 AAH46932 AAH68526 AAQ96872 BAA13251 BAF83371 BAF85420 EAW83558