InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICAM2

Summary

InnateDB Protein

IDBP-383425.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICAM2

Protein Name

intercellular adhesion molecule 2

Synonyms

CD102;

Species

Homo sapiens

Ensembl Protein

ENSP00000415283

InnateDB Gene

IDBG-64502 (ICAM2)

Protein Structure

UniProt Annotation

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0050776	regulation of immune response

Cellular Component

GO:0001931	uropod
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003988 Intercellular adhesion molecule
IPR013768 Intercellular adhesion molecule, N-terminal

PFAM

PF03921

PRINTS

PR01472
PR01473

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13598