Version 5.4
Homo sapiens Protein: BLNK
Summary
InnateDB Protein IDBP-383504.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLNK
Protein Name B-cell linker
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397487
InnateDB Gene IDBG-83724 (BLNK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0030183 B cell differentiation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WV28
PhosphoSite PhosphoSite-Q8WV28
TrEMBL Q2MD56
UniProt Splice Variant
Entrez Gene 29760
UniGene Hs.665244
RefSeq NP_001245370
HUGO HGNC:14211
OMIM 604515
CCDS CCDS58091
HPRD 05153
IMGT
EMBL AC021037 AF068180 AF068181 AF180740 AF180741 AF180742 AF180743 AF180744 AF180745 AF180746 AF180747 AF180748 AF180749 AF180750 AF180751 AF180752 AF180753 AF180754 AF180755 AF180756 AM180330 AM180332 AM180337 BC018906
GenPept AAC39936 AAC39937 AAF20382 AAF20383 AAH18906 CAJ55324 CAJ55326 CAJ55331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca