Version 5.4
Homo sapiens Protein: NEUROD4
Summary
InnateDB Protein IDBP-38352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEUROD4
Protein Name neurogenic differentiation 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000242994
InnateDB Gene IDBG-38350 (NEUROD4)
Protein Structure
UniProt Annotation
Function Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0007405 neuroblast proliferation
GO:0010001 glial cell differentiation
GO:0035881 amacrine cell differentiation
GO:0043010 camera-type eye development
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0048666 neuron development
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function
PFAM PF00010
PF12533
PRINTS
PIRSF PIRSF015618
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HD90
PhosphoSite PhosphoSite-Q9HD90
TrEMBL Q8IW56
UniProt Splice Variant
Entrez Gene 58158
UniGene Hs.591024
RefSeq NP_067014
HUGO HGNC:13802
OMIM 611635
CCDS CCDS8886
HPRD 14826
IMGT
EMBL AC027287 AF203901 AK314136 BC040961 CH471054
GenPept AAF99097 AAH40961 BAG36826 EAW96803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca