InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGLL

Summary

InnateDB Protein

IDBP-383575.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGLL

Protein Name

monoglyceride lipase

Synonyms

HU-K5; HUK5; MAGL; MGL;

Species

Homo sapiens

Ensembl Protein

ENSP00000404146

InnateDB Gene

IDBG-55027 (MGLL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0047372	acylglycerol lipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006644	phospholipid metabolic process
GO:0006954	inflammatory response
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009966	regulation of signal transduction
GO:0019369	arachidonic acid metabolic process
GO:0019433	triglyceride catabolic process
GO:0030168	platelet activation
GO:0036155	acylglycerol acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046464	acylglycerol catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050727	regulation of inflammatory response
GO:0051930	regulation of sensory perception of pain
GO:2000124	regulation of endocannabinoid signaling pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000801 Putative esterase
IPR002921 Fungal lipase-like domain
IPR013094 Alpha/beta hydrolase fold-3
IPR022742 Putative lysophospholipase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00756
PF01764
PF07859
PF12146

PRINTS

PR00111

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99685