InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMS19

Summary

InnateDB Protein

IDBP-383976.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMS19

Protein Name

MMS19 nucleotide excision repair homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395045

InnateDB Gene

IDBG-85105 (MMS19)

Protein Structure

UniProt Annotation

Function

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. {ECO:0000269PubMed:11071939, ECO:0000269PubMed:11328871, ECO:0000269PubMed:20797633, ECO:0000269PubMed:22678361, ECO:0000269PubMed:22678362}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle.

Disease Associations

Tissue Specificity

Ubiquitously expressed with higher expression in testis. {ECO:0000269PubMed:11071939, ECO:0000269PubMed:11328871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	182 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030331	estrogen receptor binding
GO:0030674	protein binding, bridging

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007059	chromosome segregation
GO:0009725	response to hormone
GO:0016226	iron-sulfur cluster assembly
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated