Version 5.4
Homo sapiens Protein: TTYH2
Summary
InnateDB Protein IDBP-384007.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTYH2
Protein Name tweety homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000394576
InnateDB Gene IDBG-67003 (TTYH2)
Protein Structure
UniProt Annotation
Function Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. {ECO:0000269PubMed:15010458}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. {ECO:0000269PubMed:11597145, ECO:0000269PubMed:17569141}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID
InterPro IPR006990 Tweety
PFAM PF04906
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSA4
PhosphoSite PhosphoSite-Q9BSA4
TrEMBL
UniProt Splice Variant
Entrez Gene 94015
UniGene Hs.27935
RefSeq NP_443101
HUGO HGNC:13877
OMIM 608855
CCDS CCDS45770
HPRD 16394
IMGT
EMBL AC100786 AF319952 AK091085 AK126955 BC005168 BC107492 BC107602 BX647912
GenPept AAH05168 AAI07493 AAI07603 AAL16784 BAC03579 BAG54409 CAH10576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca