InnateDB Protein
|
IDBP-384070.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MUC3A
|
Protein Name
|
mucin 3A, cell surface associated
|
Synonyms
|
MUC-3A; MUC3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000393306
|
InnateDB Gene
|
IDBG-32641 (MUC3A)
|
Protein Structure
|
|
Function |
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. {ECO:0000269PubMed:10405327}.
|
Subcellular Localization |
Isoform 1: Membrane; Single-pass membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.Isoform 4: Secreted.Isoform 5: Secreted.
|
Disease Associations |
|
Tissue Specificity |
Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder. {ECO:0000269PubMed:11289722}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005201
|
extracellular matrix structural constituent
|
GO:0005515
|
protein binding
|
GO:0030197
|
extracellular matrix constituent, lubricant activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000742
Epidermal growth factor-like domain
|
PFAM |
PF00008
|
PRINTS |
|
PIRSF |
|
SMART |
SM00181
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q02505
|
PhosphoSite |
PhosphoSite-Q02505
|
TrEMBL |
Q7LDU4
|
UniProt Splice Variant |
|
Entrez Gene |
4584
|
UniGene |
Hs.727333
|
RefSeq |
XP_003846779
|
HUGO |
HGNC:7513
|
OMIM |
158371
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AB038782
AC105446
AC118759
AF007190
AF007193
AF007194
AF007196
AF113616
AF143371
AF143372
AF143373
AY307930
JQ511939
M55405
M55406
|
GenPept |
AAA63772
AAA63773
AAB84383
AAC02268
AAC02271
AAC02272
AAD45882
AAD45883
AAD45884
AAF13032
AAQ73824
AFG72974
BAB12116
|
|
|