Version 5.4
Homo sapiens Protein: MAFA
Summary
InnateDB Protein IDBP-38416.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAFA
Protein Name v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328364
InnateDB Gene IDBG-38414 (MAFA)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000269PubMed:12011435, ECO:0000269PubMed:12368292, ECO:0000269PubMed:15665000, ECO:0000269PubMed:15993959, ECO:0000269PubMed:18042454, ECO:0000269PubMed:19143053}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:11416124, ECO:0000269PubMed:12368292}. Note=Detected in nuclei of pancreas islet beta cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007263 nitric oxide mediated signal transduction
GO:0009749 response to glucose
GO:0030073 insulin secretion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004826 Basic leucine zipper domain, Maf-type
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
IPR013592 Maf transcription factor, N-terminal
PFAM PF03131
PF00170
PF07716
PF08383
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHW3
PhosphoSite PhosphoSite-Q8NHW3
TrEMBL D4Q8H3
UniProt Splice Variant
Entrez Gene 389692
UniGene Hs.632040
RefSeq NP_963883
HUGO HGNC:23145
OMIM 610303
CCDS CCDS34955
HPRD 14346
IMGT
EMBL AB086960 AB205138 AC105118 AY083269
GenPept AAL89527 BAC20389 BAJ04327

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca