Version 5.4
Homo sapiens Protein: HID1
Summary
InnateDB Protein IDBP-384238.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HID1
Protein Name chromosome 17 open reading frame 28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000413520
InnateDB Gene IDBG-67794 (HID1)
Protein Structure
UniProt Annotation
Function May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269PubMed:11281419}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21337012}. Golgi apparatus membrane {ECO:0000269PubMed:21337012}; Lipid- anchor {ECO:0000269PubMed:21337012}. Note=Shuttles between the cytosol and the Golgi apparatus.
Disease Associations
Tissue Specificity Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines. {ECO:0000269PubMed:11281419, ECO:0000269PubMed:21337012}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0031001 response to brefeldin A
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005881 cytoplasmic microtubule
GO:0070062 extracellular vesicular exosome
GO:0090498 extrinsic component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR019142 Dymeclin
PFAM PF09742
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IV36
PhosphoSite PhosphoSite-Q8IV36
TrEMBL Q8NC03
UniProt Splice Variant
Entrez Gene 283987
UniGene Hs.11067
RefSeq NP_085133
HUGO HGNC:15736
OMIM 605752
CCDS CCDS32726
HPRD 05766
IMGT
EMBL AK074401 AK075111 AK304081 AL137556 BC032219 BC035372
GenPept AAH32219 AAH35372 BAB85070 BAC11407 BAG64988 CAB70810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca