InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUMO2

Summary

InnateDB Protein

IDBP-384276.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUMO2

Protein Name

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

Synonyms

HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3;

Species

Homo sapiens

Ensembl Protein

ENSP00000405965

InnateDB Gene

IDBG-83067 (SUMO2)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. {ECO:0000269PubMed:18408734, ECO:0000269PubMed:18538659, ECO:0000269PubMed:21965678, ECO:0000269PubMed:9556629}.

Subcellular Localization

Nucleus. Nucleus, PML body.

Disease Associations

Tissue Specificity

Broadly expressed. {ECO:0000269PubMed:9556629}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1721 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1721 [view]
Protein-Protein	1716 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0016925	protein sumoylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter