InnateDB Protein
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IDBP-384277.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SUMO2
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Protein Name
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SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
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Synonyms
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HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400886
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InnateDB Gene
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IDBG-83067 (SUMO2)
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Protein Structure
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Function |
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. {ECO:0000269PubMed:18408734, ECO:0000269PubMed:18538659, ECO:0000269PubMed:21965678, ECO:0000269PubMed:9556629}.
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Subcellular Localization |
Nucleus. Nucleus, PML body.
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Disease Associations |
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Tissue Specificity |
Broadly expressed. {ECO:0000269PubMed:9556629}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1721 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1721
[view]
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Protein-Protein |
1716
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
4
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
GO:0016925
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protein sumoylation
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GO:0032436
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positive regulation of proteasomal ubiquitin-dependent protein catabolic process
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GO:0043687
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post-translational protein modification
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GO:0044267
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cellular protein metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR022617
Rad60/SUMO-like domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF11976
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61956
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PhosphoSite |
PhosphoSite-P61956
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6613
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UniGene |
Hs.709384
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RefSeq |
NP_001005849
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HUGO |
HGNC:11125
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OMIM |
603042
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CCDS |
CCDS45773
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HPRD |
04332
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IMGT |
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EMBL |
AC022211
AK311837
BC008450
BC016775
BC022340
BC062713
BC068465
BC070159
BC071645
BC071646
BC107853
BF978876
CH471099
L76416
X99585
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GenPept |
AAD45399
AAH08450
AAH16775
AAH22340
AAH62713
AAH68465
AAH70159
AAH71645
AAH71646
AAI07854
BAG34779
CAA67897
EAW89249
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