InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF3C2

Summary

InnateDB Protein

IDBP-38455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF3C2

Protein Name

general transcription factor IIIC, polypeptide 2, beta 110kDa

Synonyms

TFIIIC-BETA; TFIIIC110;

Species

Homo sapiens

Ensembl Protein

ENSP00000352536

InnateDB Gene

IDBG-38453 (GTF3C2)

Protein Structure

UniProt Annotation

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0010467	gene expression
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0042797	tRNA transcription from RNA polymerase III promoter