InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK3

Summary

InnateDB Protein

IDBP-384637.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK3

Protein Name

cyclin-dependent kinase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410561

InnateDB Gene

IDBG-408965 (CDK3)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner. {ECO:0000269PubMed:15084261, ECO:0000269PubMed:18794154, ECO:0000269PubMed:8846921}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in cancer cell lines and glioblastoma tissue. {ECO:0000269PubMed:18794154}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0045023	G0 to G1 transition
GO:0051726	regulation of cell cycle

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt