Version 5.4
Homo sapiens Protein: PLS1
Summary
InnateDB Protein IDBP-384658.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLS1
Protein Name plastin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387890
InnateDB Gene IDBG-59656 (PLS1)
Protein Structure
UniProt Annotation
Function Actin-bundling protein in the absence of calcium.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach. {ECO:0000269PubMed:8139549}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR002048 EF-hand domain
PFAM PF00307
PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00033
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14651
PhosphoSite PhosphoSite-Q14651
TrEMBL C9JYI1
UniProt Splice Variant
Entrez Gene 5357
UniGene Hs.707046
RefSeq NP_001138791
HUGO HGNC:9090
OMIM 602734
CCDS CCDS3125
HPRD 04110
IMGT
EMBL AC072028 AC134509 AK290316 BC031083 CH471052 L20826
GenPept AAA19869 AAH31083 BAF83005 EAW78965 EAW78967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca