InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLSCR4

Summary

InnateDB Protein

IDBP-384722.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLSCR4

Protein Name

phospholipid scramblase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000415605

InnateDB Gene

IDBG-60083 (PLSCR4)

Protein Structure

UniProt Annotation

Function

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0017128	phospholipid scramblase activity
GO:0019899	enzyme binding
GO:0042609	CD4 receptor binding