InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ORC5

Summary

InnateDB Protein

IDBP-384773.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ORC5

Protein Name

origin recognition complex, subunit 5

Synonyms

ORC5L; ORC5P; ORC5T; PPP1R117;

Species

Homo sapiens

Ensembl Protein

ENSP00000395747

InnateDB Gene

IDBG-34679 (ORC5)

Protein Structure

UniProt Annotation

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Abundant in spleen, ovary, prostate, testis, and colon mucosa. {ECO:0000269PubMed:9765232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation

Cellular Component

GO:0000808	origin recognition complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm