InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRPSAP1

Summary

InnateDB Protein

IDBP-384785.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPSAP1

Protein Name

phosphoribosyl pyrophosphate synthetase-associated protein 1

Synonyms

PAP39;

Species

Homo sapiens

Ensembl Protein

ENSP00000414624

InnateDB Gene

IDBG-69636 (PRPSAP1)

Protein Structure

UniProt Annotation

Function

Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004749	ribose phosphate diphosphokinase activity
GO:0004857	enzyme inhibitor activity
GO:0019900	kinase binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0009165	nucleotide biosynthetic process
GO:0033673	negative regulation of kinase activity

Cellular Component

GO:0002189	ribose phosphate diphosphokinase complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR005946 Ribose-phosphate diphosphokinase
IPR029057 Phosphoribosyltransferase-like

PFAM

PF14572

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14558

PhosphoSite

PhosphoSite-Q14558

TrEMBL

C9JUN4

UniProt Splice Variant

Entrez Gene

5635

UniGene

Hs.77498

RefSeq

NP_002757

HUGO

HGNC:9466

OMIM

601249

CCDS

CCDS11743

HPRD

03151

IMGT

EMBL

AC090699 AK298171 AK312637 BC009012 CH471099 D61391

GenPept

AAH09012 BAA09612 BAG35521 BAG60443 EAW89386 EAW89387