InnateDB Protein
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IDBP-384975.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OMA1
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Protein Name
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OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000416495
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InnateDB Gene
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IDBG-99205 (OMA1)
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Protein Structure
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Function |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000269PubMed:20038677}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000305PubMed:20038677}; Multi-pass membrane protein {ECO:0000305PubMed:20038677}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. {ECO:0000269PubMed:12886954}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q96E52
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TrEMBL |
X6RL62
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UniProt Splice Variant |
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Entrez Gene |
115209
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UniGene |
Hs.425769
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RefSeq |
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HUGO |
HGNC:29661
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OMIM |
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CCDS |
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HPRD |
14879
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IMGT |
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EMBL |
AL109845
AL365187
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GenPept |
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