InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTO2

Summary

InnateDB Protein

IDBP-385165.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTO2

Protein Name

glutathione S-transferase omega 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390986

InnateDB Gene

IDBG-88870 (GSTO2)

Protein Structure

UniProt Annotation

Function

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). {ECO:0000269PubMed:15970797}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis. {ECO:0000269PubMed:12618591}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0045174	glutathione dehydrogenase (ascorbate) activity
GO:0050610	methylarsonate reductase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006805	xenobiotic metabolic process
GO:0019852	L-ascorbic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0071243	cellular response to arsenic-containing substance
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002109 Glutaredoxin
IPR004045 Glutathione S-transferase, N-terminal
IPR005442 Glutathione S-transferase, omega-class
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM