InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCHL3

Summary

InnateDB Protein

IDBP-38517.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCHL3

Protein Name

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Synonyms

UCH-L3;

Species

Homo sapiens

Ensembl Protein

ENSP00000366819

InnateDB Gene

IDBG-38513 (UCHL3)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. {ECO:0000269PubMed:19154770, ECO:0000269PubMed:21762696, ECO:0000269PubMed:22689415, ECO:0000269PubMed:2530630, ECO:0000269PubMed:9790970}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269PubMed:9790970}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	65 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0043130	ubiquitin binding