Version 5.4
Homo sapiens Protein: THAP5
Summary
InnateDB Protein IDBP-385215.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THAP5
Protein Name THAP domain containing 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400500
InnateDB Gene IDBG-36444 (THAP5)
Protein Structure
UniProt Annotation
Function May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.
Subcellular Localization Nucleus {ECO:0000269PubMed:19502560}.
Disease Associations
Tissue Specificity Highly expressed in the heart. Also found in brain and skeletal muscle. {ECO:0000269PubMed:19502560}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007049 cell cycle
GO:0045786 negative regulation of cell cycle
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z6K1
PhosphoSite PhosphoSite-Q7Z6K1
TrEMBL
UniProt Splice Variant
Entrez Gene 168451
UniGene Hs.743374
RefSeq NP_001274530
HUGO HGNC:23188
OMIM 612534
CCDS CCDS47687
HPRD 15498
IMGT
EMBL BC053634 CH236947
GenPept AAH53634 EAL24383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca