InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPBP1

Summary

InnateDB Protein

IDBP-385355.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPBP1

Protein Name

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

Synonyms

FES1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398244

InnateDB Gene

IDBG-70495 (HSPBP1)

Protein Structure

UniProt Annotation

Function

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269PubMed:10786638, ECO:0000269PubMed:12651857, ECO:0000269PubMed:15215316, ECO:0000269PubMed:9830037}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9830037}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006457	protein folding
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)