Version 5.4
Homo sapiens Protein: FNDC3B
Summary
InnateDB Protein IDBP-385436.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNDC3B
Protein Name fibronectin type III domain containing 3B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000389094
InnateDB Gene IDBG-65077 (FNDC3B)
Protein Structure
UniProt Annotation
Function May be a positive regulator of adipogenesis. {ECO:0000269PubMed:15564382}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non- adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis. {ECO:0000269PubMed:15564382}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
PFAM PF00041
PF01108
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53EP0
PhosphoSite PhosphoSite-Q53EP0
TrEMBL
UniProt Splice Variant
Entrez Gene 64778
UniGene Hs.743266
RefSeq
HUGO HGNC:24670
OMIM 611909
CCDS CCDS3217
HPRD 10943
IMGT
EMBL AB098597 AF543840 AK027052 AK075220 AK127826 AK223599 AK314478 AL157482 AY358146 AY358367 BC012204 BC033635 BC039297 CH471052
GenPept AAH12204 AAH33635 AAH39297 AAN65261 AAQ88513 AAQ88733 BAB15639 BAC11480 BAC53727 BAD97319 BAG37083 BAG54580 CAB75672 EAW78472 EAW78474 EAW78475 EAW78476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca