InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VTI1A

Summary

InnateDB Protein

IDBP-385507.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VTI1A

Protein Name

vesicle transport through interaction with t-SNAREs homolog 1A (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395017

InnateDB Gene

IDBG-89850 (VTI1A)

Protein Structure

UniProt Annotation

Function

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269PubMed:18195106, ECO:0000269PubMed:19138172}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000269PubMed:19138172}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031201	SNARE complex