InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AURKC

Summary

InnateDB Protein

IDBP-385547.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKC

Protein Name

aurora kinase C

Synonyms

AIE2; AIK3; ARK3; AurC; aurora-C; SPGF5; STK13;

Species

Homo sapiens

Ensembl Protein

ENSP00000407162

InnateDB Gene

IDBG-71872 (AURKC)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269PubMed:15316025, ECO:0000269PubMed:15499654, ECO:0000269PubMed:15670791, ECO:0000269PubMed:15938719, ECO:0000269PubMed:21493633, ECO:0000269PubMed:21531210}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Disease Associations

Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269PubMed:17435757, ECO:0000269PubMed:21733974}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. {ECO:0000269PubMed:15670791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007126	meiotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0016570	histone modification
GO:0032467	positive regulation of cytokinesis
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt