InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO7B

Summary

InnateDB Protein

IDBP-385650.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO7B

Protein Name

myosin VIIB

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000415090

InnateDB Gene

IDBG-69130 (MYO7B)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be have a role in the apical membranes of transporting epithelia (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005856	cytoskeleton
GO:0016324	apical plasma membrane
GO:0016459	myosin complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR011511 Variant SH3 domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM