InnateDB Protein
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IDBP-385707.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEPDC1
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Protein Name
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DEP domain containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000412292
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InnateDB Gene
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IDBG-99608 (DEPDC1)
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Protein Structure
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Function |
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269PubMed:20587513}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17452976, ECO:0000269PubMed:20587513}. Note=Colocalizes with ZNF224 at the nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO:0000269PubMed:17452976}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000591
DEP domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00610
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PRINTS |
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PIRSF |
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SMART |
SM00049
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TIGRFAMs |
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Modification |
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SwissProt |
Q5TB30
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PhosphoSite |
PhosphoSite-Q5TB30
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TrEMBL |
E9PL61
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UniProt Splice Variant |
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Entrez Gene |
55635
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UniGene |
Hs.641921
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RefSeq |
NP_001107592
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HUGO |
HGNC:22949
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OMIM |
612002
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CCDS |
CCDS44159
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HPRD |
10879
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IMGT |
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EMBL |
AB281187
AB281274
AJ278112
AK000490
AK022792
AL138789
AL139413
BC003511
BC065304
CH471059
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GenPept |
AAH03511
AAH65304
BAA91201
BAB14246
BAF91373
BAF91374
CAB92444
CAI22441
CAI22442
CAI22443
EAX06475
EAX06476
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