Version 5.4
Homo sapiens Protein: CFTR
Summary
InnateDB Protein IDBP-385739.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFTR
Protein Name cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Synonyms ABC35; ABCC7; CF; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR;
Species Homo sapiens
Ensembl Protein ENSP00000389119
InnateDB Gene IDBG-37713 (CFTR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 316 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 316 [view]
Protein-Protein 303 [view]
Protein-DNA 11 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005260 channel-conductance-controlling ATPase activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0045087 innate immune response (InnateDB)
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005291 Cyclic AMP-dependent chloride channel
IPR009147 Cystic fibrosis transmembrane conductance regulator
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00664
PF13748
PF00005
PRINTS PR01851
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9UML7
UniProt Splice Variant
Entrez Gene 1080
UniGene Hs.661104
RefSeq
HUGO HGNC:1884
OMIM 602421
CCDS
HPRD 03883
IMGT
EMBL AC000061 AC000111 AC004240 AJ574940 AJ574941 AJ574942 AJ574944 AJ574945 AJ574946 AJ574947 AJ574948 AJ574950 AJ574951 AJ574952 AJ574953 AJ574954 AJ574955 AJ574956 AJ574957 AJ574958 AJ574959 AJ574963 AJ574964 AJ574965 AJ574966 AJ574967 AJ574969 AJ574970 AJ574971 AJ574972 AJ574973 AJ574974 AJ574975 AJ574976 AJ574977 AJ574978 AJ574979 AJ574980 AJ574981 AJ574982 AJ574983 AJ574984 AJ574985 AJ574986 AJ574987 AJ574988 AJ574989 AJ574990 AJ574991 AJ574992 AJ574993 AJ574994 AJ574999 AJ575000 AJ575001 AJ575002 AJ575003 AJ575004 AJ575005 AJ575006 AJ575007 AJ575008 AJ575009 AJ575010 AJ575011 AJ575012 AJ575013 AJ575014 AJ575015 AJ575016 AJ575017 AJ575018 AJ575019 AJ575020 AJ575021 AJ575022 AJ575023 AJ575024 AJ575025 AJ575026 AJ575027 AJ575028 AJ575029 AJ575030 AJ575031 AJ575032 AJ575033 AJ575034 AJ575035 AJ575036 AJ575037 AJ575038 AJ575039 AJ575040 AJ575041 AJ575042 AJ575043 AJ575044 AJ575045 AJ575046 AJ575047 AJ575048 AJ575049 AJ575050 AY848829 AY848831 AY848832 EF466097 L49339 M96936
GenPept AAB59382 AAC41928 AAW33656 AAW33658 AAW33659 ABO61515 CAE00654 CAE00655 CAE00656 CAE00658 CAE00659 CAE00660 CAE00661 CAE00662 CAE00664 CAE00665 CAE00666 CAE00667 CAE00668 CAE00669 CAE00670 CAE00671 CAE00672 CAE00673 CAE00677 CAE00678 CAE00679 CAE00680 CAE00681 CAE00683 CAE00684 CAE00685 CAE00686 CAE00687 CAE00688 CAE00689 CAE00690 CAE00691 CAE00692 CAE00693 CAE00694 CAE00695 CAE00696 CAE00697 CAE00698 CAE00699 CAE00700 CAE00701 CAE00702 CAE00703 CAE00704 CAE00705 CAE00706 CAE00707 CAE00708 CAE00713 CAE00714 CAE00715 CAE00716 CAE00717 CAE00718 CAE00719 CAE00720 CAE00721 CAE00722 CAE00723 CAE00724 CAE00725 CAE00726 CAE00727 CAE00728 CAE00729 CAE00730 CAE00731 CAE00732 CAE00733 CAE00734 CAE00735 CAE00736 CAE00737 CAE00738 CAE00739 CAE00740 CAE00741 CAE00742 CAE00743 CAE00744 CAE00745 CAE00746 CAE00747 CAE00748 CAE00749 CAE00750 CAE00751 CAE00752 CAE00753 CAE00754 CAE00755 CAE00756 CAE00757 CAE00758 CAE00759 CAE00760 CAE00761 CAE00762 CAE00763 CAE00764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca