InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLHL24

Summary

InnateDB Protein

IDBP-385771.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL24

Protein Name

kelch-like 24 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395012

InnateDB Gene

IDBG-67011 (KLHL24)

Protein Structure

UniProt Annotation

Function

Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. {ECO:0000250}.

Subcellular Localization

Perikaryon. Cell projection, axon {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0030424	axon
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt