InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FEZF1

Summary

InnateDB Protein

IDBP-385884.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FEZF1

Protein Name

FEZ family zinc finger 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000411145

InnateDB Gene

IDBG-38545 (FEZF1)

Protein Structure

UniProt Annotation

Function

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19318583}.

Disease Associations

Tissue Specificity

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues. {ECO:0000269PubMed:19318583}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0021537	telencephalon development
GO:0021772	olfactory bulb development
GO:0021797	forebrain anterior/posterior pattern specification
GO:0030900	forebrain development
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated