Version 5.4
Homo sapiens Protein: FEZF1
Summary
InnateDB Protein IDBP-385886.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FEZF1
Protein Name FEZ family zinc finger 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392727
InnateDB Gene IDBG-38545 (FEZF1)
Protein Structure
UniProt Annotation
Function Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19318583}.
Disease Associations
Tissue Specificity Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues. {ECO:0000269PubMed:19318583}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0PJY2
PhosphoSite PhosphoSite-A0PJY2
TrEMBL C9J0C5
UniProt Splice Variant
Entrez Gene 389549
UniGene Hs.553970
RefSeq NP_001153736
HUGO HGNC:22788
OMIM 613301
CCDS CCDS55157
HPRD 18614
IMGT
EMBL AC015983 AK300742 BC127714 BC127715 BC136684 BC144367 CH236947
GenPept AAI27715 AAI27716 AAI36685 AAI44368 BAG62411 EAL24342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca