InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD164

Summary

InnateDB Protein

IDBP-385899.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD164

Protein Name

CD164 molecule, sialomucin

Synonyms

endolyn; MGC-24; MUC-24;

Species

Homo sapiens

Ensembl Protein

ENSP00000402237

InnateDB Gene

IDBG-95097 (CD164)

Protein Structure

UniProt Annotation

Function

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269PubMed:11027692}. Endosome membrane {ECO:0000269PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269PubMed:11027692}. Cell membrane {ECO:0000269PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269PubMed:11027692}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. {ECO:0000269PubMed:10878358, ECO:0000269PubMed:11027692, ECO:0000269PubMed:1478919, ECO:0000269PubMed:16859559, ECO:0000269PubMed:9763543}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	4 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0030097	hemopoiesis

Cellular Component

GO:0005576	extracellular region
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0010008	endosome membrane