Version 5.4
Homo sapiens Protein: FAM123C
Summary
InnateDB Protein IDBP-385981.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM123C
Protein Name family with sequence similarity 123C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392700
InnateDB Gene IDBG-69987 (FAM123C)
Protein Structure
UniProt Annotation
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR019003 Uncharacterised protein family FAM123
PFAM PF09422
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N944
PhosphoSite PhosphoSite-Q8N944
TrEMBL C9JS07
UniProt Splice Variant
Entrez Gene 205147
UniGene Hs.369289
RefSeq NP_001098665
HUGO HGNC:26771
OMIM
CCDS CCDS2164
HPRD 08241
IMGT
EMBL AC010984 AC140481 AK095696 AK289525 AK291424 BC113445 BC113447 BC143806 CH471250
GenPept AAI13446 AAI13448 AAI43807 AAY24355 BAC04612 BAF82214 BAF84113 EAW51273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca