Version 5.4
Homo sapiens Protein: NANOS1
Summary
InnateDB Protein IDBP-386023.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NANOS1
Protein Name nanos homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393275
InnateDB Gene IDBG-90977 (NANOS1)
Protein Structure
UniProt Annotation
Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269PubMed:17047063, ECO:0000269PubMed:18223680}.
Subcellular Localization Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
Disease Associations Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. {ECO:0000269PubMed:23315541}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. {ECO:0000269PubMed:12690449, ECO:0000269PubMed:17047063, ECO:0000269PubMed:18223680, ECO:0000269PubMed:19168546, ECO:0000269PubMed:21421998}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030371 translation repressor activity
Biological Process
GO:0010631 epithelial cell migration
GO:0016477 cell migration
GO:0017148 negative regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR024161 Zinc finger, nanos-type
PFAM PF05741
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WY41
PhosphoSite PhosphoSite-Q8WY41
TrEMBL Q5T9H5
UniProt Splice Variant
Entrez Gene 340719
UniGene Hs.591918
RefSeq NP_955631
HUGO HGNC:23044
OMIM 608226
CCDS CCDS7607
HPRD 16302
IMGT
EMBL AF275269 AF458985 AL157788
GenPept AAL36982 AAQ04765 CAI14718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca