Version 5.4
Homo sapiens Protein: HILPDA
Summary
InnateDB Protein IDBP-386105.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HILPDA
Protein Name chromosome 7 open reading frame 68
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000388871
InnateDB Gene IDBG-39804 (HILPDA)
Protein Structure
UniProt Annotation
Function Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269PubMed:15930302, ECO:0000269PubMed:20624928}.
Subcellular Localization Lipid droplet. Secreted. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level). {ECO:0000269PubMed:15930302, ECO:0000269PubMed:20624928, ECO:0000269PubMed:21614900}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006950 response to stress
GO:0008284 positive regulation of cell proliferation
GO:0010884 positive regulation of lipid storage
GO:0035425 autocrine signaling
Cellular Component
GO:0005615 extracellular space
GO:0005811 lipid particle
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5L2
PhosphoSite PhosphoSite-Q9Y5L2
TrEMBL
UniProt Splice Variant
Entrez Gene 29923
UniGene Hs.706124
RefSeq NP_001092256
HUGO HGNC:28859
OMIM
CCDS CCDS5802
HPRD 17105
IMGT
EMBL AF144755 AK222583 BC001863 BC093742 BC112183 CH236947
GenPept AAD37585 AAH01863 AAH93742 AAI12184 BAD96303 EAL24309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca