InnateDB Protein
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IDBP-386157.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2H
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Protein Name
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polymerase (RNA) II (DNA directed) polypeptide H
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Synonyms
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RPABC3; RPB17; RPB8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392913
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InnateDB Gene
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IDBG-68158 (POLR2H)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. {ECO:0000269PubMed:9852112}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000269PubMed:9852112, ECO:0000269Ref.6}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
64
[view]
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Protein-Protein |
64
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005570
RNA polymerase, Rpb8
IPR012340
Nucleic acid-binding, OB-fold
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PFAM |
PF03870
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PRINTS |
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PIRSF |
PIRSF000779
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SMART |
SM00658
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TIGRFAMs |
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Modification |
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SwissProt |
P52434
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PhosphoSite |
PhosphoSite-P52434
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TrEMBL |
C9JLU1
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UniProt Splice Variant |
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Entrez Gene |
5437
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UniGene |
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RefSeq |
NP_006223
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HUGO |
HGNC:9195
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OMIM |
606023
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CCDS |
CCDS3264
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HPRD |
09082
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IMGT |
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EMBL |
AC078797
AJ252079
AJ252080
BC000739
U37689
Z49199
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GenPept |
AAA91458
AAH00739
CAA89060
CAB92189
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