Version 5.4
Homo sapiens Protein: TMEM59L
Summary
InnateDB Protein IDBP-38618.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM59L
Protein Name transmembrane protein 59-like
Synonyms BSMAP; C19orf4;
Species Homo sapiens
Ensembl Protein ENSP00000262817
InnateDB Gene IDBG-38616 (TMEM59L)
Protein Structure
UniProt Annotation
Function Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269PubMed:20427278}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305PubMed:20427278}; Single-pass type I membrane protein {ECO:0000305PubMed:20427278}.
Disease Associations
Tissue Specificity Expressed preferentially at high level in the brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR022065 Uncharacterised protein family, TMEM59
PFAM PF12280
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UK28
PhosphoSite PhosphoSite-Q9UK28
TrEMBL A0A024R7L4
UniProt Splice Variant
Entrez Gene 25789
UniGene Hs.329850
RefSeq NP_036241
HUGO HGNC:13237
OMIM
CCDS CCDS12383
HPRD 12709
IMGT
EMBL AF186264 BC010446 CH471106
GenPept AAF00529 AAH10446 EAW84726 EAW84727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca