InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FTMT

Summary

InnateDB Protein

IDBP-38621.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FTMT

Protein Name

ferritin mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313691

InnateDB Gene

IDBG-38619 (FTMT)

Protein Structure

UniProt Annotation

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. {ECO:0000269PubMed:11323407, ECO:0000269PubMed:15201052}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11323407}.

Disease Associations

Tissue Specificity

Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine. {ECO:0000269PubMed:11323407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0008284	positive regulation of cell proliferation
GO:0051347	positive regulation of transferase activity
GO:0051349	positive regulation of lyase activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process