InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYR61

Summary

InnateDB Protein

IDBP-386348.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYR61

Protein Name

cysteine-rich, angiogenic inducer, 61

Synonyms

CCN1; GIG1; IGFBP10;

Species

Homo sapiens

Ensembl Protein

ENSP00000398736

InnateDB Gene

IDBG-100054 (CYR61)

Protein Structure

UniProt Annotation

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269PubMed:11584015}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008201	heparin binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0002041	intussusceptive angiogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003278	apoptotic process involved in heart morphogenesis
GO:0003281	ventricular septum development
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0008283	cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0010518	positive regulation of phospholipase activity
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0033690	positive regulation of osteoblast proliferation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044319	wound healing, spreading of cells
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060413	atrial septum morphogenesis
GO:0060591	chondroblast differentiation
GO:0060710	chorio-allantoic fusion
GO:0060716	labyrinthine layer blood vessel development
GO:0061036	positive regulation of cartilage development
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0072593	reactive oxygen species metabolic process
GO:2000304	positive regulation of ceramide biosynthetic process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt