Version 5.4
Homo sapiens Protein: KIF5C
Summary
InnateDB Protein IDBP-386379.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF5C
Protein Name kinesin family member 5C
Synonyms CDCBM2; KINN; NKHC; NKHC-2; NKHC2;
Species Homo sapiens
Ensembl Protein ENSP00000393379
InnateDB Gene IDBG-71896 (KIF5C)
Protein Structure
UniProt Annotation
Function Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2) [MIM:615282]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include intrauterine growth retardation, fetal akinesia, seizures, microcephaly, lack of psychomotor development, and arthrogryposis. Brain imaging shows malformations of cortical development, including polymicrogyria, gyral simplification, and thin corpus callosum. {ECO:0000269PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0006996 organelle organization
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
GO:0051028 mRNA transport
Cellular Component
GO:0005737 cytoplasm
GO:0005871 kinesin complex
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60282
PhosphoSite PhosphoSite-O60282
TrEMBL Q9UFW7
UniProt Splice Variant
Entrez Gene 3800
UniGene Hs.714134
RefSeq NP_004513
HUGO HGNC:6325
OMIM 604593
CCDS CCDS74586
HPRD
IMGT
EMBL AB011103 AC073271 AC105402 AC108512 AC144443 AC144611 AC153810 AF010146 AL117393 BC110287
GenPept AAD01436 AAI10288 AAX82030 AAX82035 AAX82036 AAY24013 BAA25457 CAB55895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca