InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADIPOQ

Summary

InnateDB Protein

IDBP-386456.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADIPOQ

Protein Name

adiponectin, C1Q and collagen domain containing

Synonyms

ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28;

Species

Homo sapiens

Ensembl Protein

ENSP00000389814

InnateDB Gene

IDBG-69167 (ADIPOQ)

Protein Structure

UniProt Annotation

Function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269PubMed:11479627}.

Subcellular Localization

Secreted.

Disease Associations

Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin. {ECO:0000269PubMed:10918532}. Note=The disease is caused by mutations affecting the gene represented in this entry.Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Synthesized exclusively by adipocytes and secreted into plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0033691	sialic acid binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0006006	glucose metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006635	fatty acid beta-oxidation
GO:0007584	response to nutrient
GO:0007623	circadian rhythm
GO:0009744	response to sucrose stimulus
GO:0009749	response to glucose
GO:0009967	positive regulation of signal transduction
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875	positive regulation of cholesterol efflux
GO:0010906	regulation of glucose metabolic process
GO:0014823	response to activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0019395	fatty acid oxidation
GO:0030336	negative regulation of cell migration
GO:0030853	negative regulation of granulocyte differentiation
GO:0031667	response to nutrient levels
GO:0031953	negative regulation of protein autophosphorylation
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032757	positive regulation of interleukin-8 production
GO:0032869	cellular response to insulin stimulus
GO:0033034	positive regulation of myeloid cell apoptotic process
GO:0033211	adiponectin-activated signaling pathway
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0034383	low-density lipoprotein particle clearance
GO:0034612	response to tumor necrosis factor
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045599	negative regulation of fat cell differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721	negative regulation of gluconeogenesis
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045923	positive regulation of fatty acid metabolic process
GO:0046326	positive regulation of glucose import
GO:0046888	negative regulation of hormone secretion
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050765	negative regulation of phagocytosis
GO:0050805	negative regulation of synaptic transmission
GO:0050873	brown fat cell differentiation
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051899	membrane depolarization
GO:0060081	membrane hyperpolarization
GO:0070208	protein heterotrimerization
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070543	response to linoleic acid
GO:0070994	detection of oxidative stress
GO:0071320	cellular response to cAMP
GO:0071639	positive regulation of monocyte chemotactic protein-1 production
GO:0071872	cellular response to epinephrine stimulus
GO:0072659	protein localization to plasma membrane
GO:0090317	negative regulation of intracellular protein transport
GO:1900121	negative regulation of receptor binding
GO:2000279	negative regulation of DNA biosynthetic process
GO:2000467	positive regulation of glycogen (starch) synthase activity
GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000534	positive regulation of renal albumin absorption
GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000590	negative regulation of metanephric mesenchymal cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome