Version 5.4
Homo sapiens Protein: LEPREL1
Summary
InnateDB Protein IDBP-386590.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEPREL1
Protein Name leprecan-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408947
InnateDB Gene IDBG-69605 (LEPREL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019797 procollagen-proline 3-dioxygenase activity
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0019511 peptidyl-proline hydroxylation
GO:0030198 extracellular matrix organization
GO:0032963 collagen metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005604 basement membrane
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
IPR006620 Prolyl 4-hydroxylase, alpha subunit
PFAM PF03171
PF13640
PRINTS
PIRSF
SMART SM00702
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVL5
PhosphoSite PhosphoSite-Q8IVL5
TrEMBL C9JSL4
UniProt Splice Variant
Entrez Gene 55214
UniGene Hs.374191
RefSeq NP_001127890
HUGO HGNC:19317
OMIM 610341
CCDS CCDS46981
HPRD 17270
IMGT
EMBL AC016966 AC063939 AC099660 AJ430351 AK001580 AK056447 AK125134 BC005029 CH471052
GenPept AAH05029 BAA91769 BAG51712 BAG54151 CAD23039 EAW78109 EAW78110 EAW78111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca