Version 5.4
Homo sapiens Protein: GMNC
Summary
InnateDB Protein IDBP-386630.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMNC
Protein Name geminin coiled-coil domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406164
InnateDB Gene IDBG-69762 (GMNC)
Protein Structure
UniProt Annotation
Function Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L onto replication origins (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Associates with chromatin during pre-replication complex (pre-RC) formation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
Biological Process
GO:0006260 DNA replication
GO:0007049 cell cycle
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NCL1
PhosphoSite PhosphoSite-A6NCL1
TrEMBL
UniProt Splice Variant
Entrez Gene 647309
UniGene Hs.518490
RefSeq NP_001140158
HUGO HGNC:40049
OMIM 614448
CCDS CCDS54697
HPRD
IMGT
EMBL AC092952
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca