Version 5.4
Homo sapiens Protein: KIAA1549
Summary
InnateDB Protein IDBP-386741.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA1549
Protein Name KIAA1549
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406661
InnateDB Gene IDBG-43389 (KIAA1549)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving KIAA1549 is found in pilocytic astrocytoma. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation. {ECO:0000269PubMed:18974108}.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCM3
PhosphoSite PhosphoSite-Q9HCM3
TrEMBL
UniProt Splice Variant
Entrez Gene 57670
UniGene Hs.629012
RefSeq NP_065961
HUGO HGNC:22219
OMIM 613344
CCDS CCDS47723
HPRD
IMGT
EMBL AB046769 AC018663 AC083868 AC093144 AL136736 AM989467 AM989468 AM989469 AM989470 AM989471 AM989472 AM989473 AM989474 AM989475 AM989476 AM989477 BC038232 BC091523
GenPept AAH38232 AAH91523 BAB13375 CAB66670 CAQ43105 CAQ43106 CAQ43107 CAQ43108 CAQ43109 CAQ43110 CAQ43111 CAQ43112 CAQ43113 CAQ43114 CAQ43115 CAQ43116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca