InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPN2

Summary

InnateDB Protein

IDBP-386776.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPN2

Protein Name

carboxypeptidase N, polypeptide 2

Synonyms

ACBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000402232

InnateDB Gene

IDBG-70221 (CPN2)

Protein Structure

UniProt Annotation

Function

The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0050790	regulation of catalytic activity
GO:0050821	protein stabilization

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22792