Version 5.4
Homo sapiens Protein: MKRN1
Summary
InnateDB Protein IDBP-386860.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKRN1
Protein Name makorin ring finger protein 1
Synonyms RNF61;
Species Homo sapiens
Ensembl Protein ENSP00000416369
InnateDB Gene IDBG-44143 (MKRN1)
Protein Structure
UniProt Annotation
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269PubMed:16785614, ECO:0000269PubMed:19536131}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10843807, ECO:0000269PubMed:16785614}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR000571 Zinc finger, CCCH-type
IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00642
PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00356
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHC7
PhosphoSite PhosphoSite-Q9UHC7
TrEMBL C9JYX8
UniProt Splice Variant
Entrez Gene 23608
UniGene Hs.743455
RefSeq NP_001138597
HUGO HGNC:7112
OMIM 607754
CCDS CCDS47725
HPRD 09673
IMGT
EMBL AB209298 AC069335 AF117233 AF192784 AF192789 AF192790 AF192791 AF192792 AF192793 AK127030 AK315552 AL136812 AM236048 BC025955 BC037400 BC064838 CH236950 CH471070
GenPept AAF17214 AAF17487 AAF18979 AAH25955 AAH37400 AAH64838 BAD92535 BAG37929 BAG54426 CAB66746 CAJ84705 EAL24026 EAW83949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca