InnateDB Protein
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IDBP-386861.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD302
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Protein Name
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CD302 molecule
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Synonyms
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BIMLEC; CLEC13A; DCL-1; DCL1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000394301
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InnateDB Gene
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IDBG-403891 (CD302)
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Protein Structure
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Function |
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. {ECO:0000269PubMed:17947679}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269PubMed:17947679}. Cell projection, microvillus {ECO:0000269PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
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Disease Associations |
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Tissue Specificity |
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed- Sternberg (HRS) cells. {ECO:0000269PubMed:12824192, ECO:0000269PubMed:17947679}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008646
Herpesvirus UL45-like
IPR016187
C-type lectin fold
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PFAM |
PF05473
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IX05
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PhosphoSite |
PhosphoSite-Q8IX05
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9936
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UniGene |
Hs.682302
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RefSeq |
NP_001185692
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HUGO |
HGNC:30843
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OMIM |
612246
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CCDS |
CCDS56139
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HPRD |
09906
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IMGT |
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EMBL |
AC009961
AF499000
AK291279
AK304422
AY314007
BC020646
D14664
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GenPept |
AAH20646
AAN77050
AAP79900
AAY14942
BAA03498
BAF83968
BAG65251
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