InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R2D

Summary

InnateDB Protein

IDBP-386899.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R2D

Protein Name

protein phosphatase 2, regulatory subunit B, delta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000399970

InnateDB Gene

IDBG-93300 (PPP2R2D)

Protein Structure

UniProt Annotation

Function

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0010458	exit from mitosis
GO:0050790	regulation of catalytic activity